Royal Air Force Typhoon FGR4s have joined forces with French warplanes in a combined operation against an hidden munitions depot in Syria used by the IS group, according to the UK's MoD.
The site, located using reconnaissance, was thought to be housing weapons and explosive materials, the statement said, and was located in hills just above Palmyra in the heart of Syria.
"The RAF jets employed precision-guided Paveway IV munitions to strike a number of entry passages providing entry to the facility... initial indications indicate the target was engaged successfully," officials stated.
There was no evidence of any civilian impact in the attack late on Saturday and all the aircraft returned safely, the MoD added.
The Typhoon FGR4s were assisted by a Voyager tanker plane.
IS - referred to as ISIS - imposed extremist governance over significant areas in Iraq and Syria before its territorial defeat in 2019.
"This action shows British leadership, and determination to operate in unison with our allies, to stamp out any re-emergence of IS and their harmful and extremist ideologies in the Middle East," UK Defence Secretary the Defence Secretary said.
British military aircraft have conducted patrols over Syria to "deter any attempted comeback" of the group after its military defeat at the climactic battle in Baghuz in 2019, the MoD reported.
"I want to thank the personnel of the UK armed forces participating in this operation for their expertise and their valour," he commented. "They were among a great many UK service members on duty over the festive period. This operation, to eliminate dangerous terrorists who endanger our safety, demonstrates how our armed forces are always on standby, all year round, ensuring Britain's security within its borders and strong abroad."
During December, the US military executed what it described as a "major assault" targeting Islamic State objectives in the country, following an attack killed two American soldiers and a civilian linguist in Palmyra.
The United Nations reports IS still has between 5,000 and 7,000 fighters in Syria and Iraq.